Characterization of the non-invasive assessment of the cutaneous microcirculation by laser Doppler perfusion scanner.

摘要: Objective:  Microcirculatory dysfunction contributes to morbidity and mortality in vascular diseases. Here, we aimed at establishing a sensitive valid method measure microvascular reactivity during post‐occlusive reactive hyperemia (PORH) using scanning laser Doppler perfusion imaging (LDPI) of the forearm. Methods:  In first series, LDPI was methodologically evaluated on volar forearm healthy volunteers (n = 10) before after one five minutes upper arm occlusion. second readings were performed 20 subjects patients with coronary artery disease (CAD). Results:  Three occlusion sufficient induce maximal vasodilation PORH as indicated by increase unit (PU) amplitude that did not further five‐minute Five‐minute led significant prolongation greater area under curve (AUC) suggesting longer lasting microvessels. The associated lower variability compared three (intraindividual variability: 9–17% vs. 12–21%; interindividual 13–24% 14–26%). CAD exhibited significantly reduced (105 ± 49 164 ± 35 PU; p < 0.001), ratio (4.7 ± 1.8 7.1 ± 1.8; AUC (1656 ± 1070 2723 ± 864 PU × minutes; p = 0.001). Conclusion:  Scanning is feasible reproducible for non‐invasive assessment cutaneous microcirculatory response PORH.