Microvascular reactivity in response to smoking and oral antioxidants in humans.

摘要: Objective: To investigate whether a daily intake of moderate dose antioxidants modifies the microcirculatory response to smoking, assuming major influence oxidative stress on microcirculation. Methods: The microvascular smoking was assessed in individual capillaries by capillaroscopy before and after two weeks treatment with oral antioxidants. Results: Smoking prolonged time peak (TtP) capillary blood flow velocity all subjects. When subjects were pre-treated ascorbate, TtP comparable baseline values untreated No significant effect vitamin E observed either or smoking. Capillary increased ascorbate as well E. However, reductions still even consumed (p < 0.0004 p 0.000008 respectively). Conclusions: This study focused capillaries, confirms that has very pronounced, direct reproducible possible demonstrate vivo human capillaries. Moderate antioxidant clearly mitigated effects induced treated similar cigarette. Thus, could be assumed play role