Effect of various glucagon/insulin molar ratios on blood ketone body levels in rats by use of osmotic minipumps
作者： Eiichi Ubukata , Osamu Mokuda , Yoshikazu Sakamoto , Naokata Shimizu
DOI: 10.1016/S0168-8227(96)01325-3
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摘要: The bihormonal control by insulin and glucagon of blood ketone body level was studied. Mixed solutions with various molar ratios (G/I) were subcutaneously infused continuously for five days use the osmotic minipump in normal rats. concentrations solution set at high G/I ratio, moderate ratio low ratio. In addition, group divided into three sub-groups: insulin, insulin. After days, rats decapitated to measure plasma body, free fatty acid (FFA), glucose, glucagon. FFA not significantly different among groups. glucose between groups, decreased group. 3-beta-hydroxybutyrate (3-OHBA) acetoacetate (AcAc) levels elevated, 3-OHBA lowered compared those Among sub-groups, there no difference AcAc levels. These results demonstrate that are controlled
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