Efficacy of a Pneumococcal Conjugate Vaccine against Acute Otitis Media

摘要: Background Ear infections are a common cause of illness during the first two years life. New conjugate vaccines may be able to prevent substantial portion cases acute otitis media caused by Streptococcus pneumoniae. Methods We enrolled 1662 infants in randomized, double-blind efficacy trial heptavalent pneumococcal polysaccharide vaccine which carrier protein is nontoxic diphtheria-toxin analogue CRM197. The children received either study or hepatitis B as control at 2, 4, 6, and 12 months age. clinical diagnosis was based on predefined criteria, bacteriologic culture middle-ear fluid obtained myringotomy. Results Of who were enrolled, 95.1 percent completed trial. With vaccine, there more local reactions than with but fewer combined whole-cell diphtheria–tetanus–pertussis Haemophilus influenzae t...