Convection-Enhanced Delivery of Polymeric Nanoparticles Encapsulating Chemotherapy in Canines with Spontaneous Supratentorial Tumors.

摘要: Background Despite aggressive multimodal treatment, survival for patients with glioblastoma remains dismal. One obstacle to improving patient outcomes is the difficulty in delivering adequate therapeutic central nervous system due presence of blood–brain barrier. Although direct drug infusion by convection-enhanced delivery (CED) can bypass barrier and facilitate intracranial tumors, determining distribution delivered problematic. Image guidance a strategy that optimize accuracy delivery. Methods Here we performed an open-label clinical trial 10 pet dogs spontaneous tumors examine target coverage polymeric magnetite nanoparticles (PMNPs) encapsulating temozolomide (TMZ). A modified small animal frame was applied head each subject, PMNPs were stereotactically center tumor. Magnetic resonance imaging (MRI) immediately postoperatively PMNP distribution, animals followed until death. Results Nine underwent without complications. No infusate backflow observed during any procedure. In 70% cases, accurately targeted tumor mass, as determined signal on immediate postoperative MRI. Conclusions These data suggest CED carrying TMZ safe lead nanoparticle region target. important adjunct CED, because unpredictable, potential missed