MLL3 , a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia
作者： Myriam Ruault , Marie Elisabeth Brun , Mario Ventura , Gérard Roizès , Albertina De Sario
DOI: 10.1016/S0378-1119(02)00392-X
关键词:
摘要: We characterized MLL3, a new human member of the TRX/MLL gene family. MLL3 is expressed in peripheral blood, placenta, pancreas, testes, and foetal thymus weakly heart, brain, lung, liver, kidney. It encodes predicted protein 4911 amino acids containing two plant homeo domains (PHD), an ATPase alpha_beta signature, high mobility group, SET (Suppressor variegation, Enhancer zeste, Trithorax) FY (phenylalanine tyrosine)-rich domains. The acid sequence domain was used to obtain phylogenetic tree MLL genes their homologues different species. closely related MLL2, Fugu mll2, Caenorhabditis elegans protein, Drosophila trithorax-related protein. Interestingly, PHD are frequently found proteins encoded by that rearranged haematological malignancies maps 7q36, chromosome region deleted myeloid disorders. Partial duplications juxtacentromeric chromosomes 1, 2, 13, 21.
elsevier.com
sci-hub.se 参考文章(26)
David L. Nelson, Stephen T. Warren, Trinucleotide repeat instability: when and where? Nature Genetics. ,vol. 4, pp. 107- 108 ,(1993) , 10.1038/NG0693-107
K. DÖhner, U. Hehmann, J. Brown, C. Hetzel, J. Stewart, G. Lowther, C. Scholl, S. FrÖhling, A. Cuneo, L. C. Tsui, P. Lichter, S. W. Scherer, H. DÖhner, Molecular Cytogenetic Characterization of a Critical Region in Bands 7q35-q36 Commonly Deleted in Malignant Myeloid Disorders Haematology and Blood Transfusion / Hämatologie und Bluttransfusion. ,vol. 92, pp. 15- 19 ,(2001) , 10.1007/978-3-642-18156-6_3
B. Tschiersch, A. Hofmann, V. Krauss, R. Dorn, G. Korge, G. Reuter, The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. The EMBO Journal. ,vol. 13, pp. 3822- 3831 ,(1994) , 10.1002/J.1460-2075.1994.TB06693.X
Sydney Brenner, Klaus Gellner, Analysis of 148 kb of genomic DNA around the wnt1 locus of Fugu rubripes. Genome Research. ,vol. 9, pp. 251- 258 ,(1999) , 10.1101/GR.9.3.251
Armin Schumacher, Terry Magnuson, Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends in Genetics. ,vol. 13, pp. 167- 170 ,(1997) , 10.1016/S0168-9525(97)01133-5
Y. Gu, T. Nakamura, H. Alder, R. Prasad, O. Canaani, G. Cimino, C.M. Croce, E. Canaani, The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene Cell. ,vol. 71, pp. 701- 708 ,(1992) , 10.1016/0092-8674(92)90603-A
V. Saha, T. Chaplin, A. Gregorini, P. Ayton, B. D. Young, The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 9737- 9741 ,(1995) , 10.1073/PNAS.92.21.9737
Rein Aasland, Toby J Gibson, A Francis Stewart, The PHD finger: Implications for chromatin-mediated transcriptional regulation Trends in Biochemical Sciences. ,vol. 20, pp. 56- 59 ,(1995) , 10.1016/S0968-0004(00)88957-4
Felix Mitelman, Recurrent chromosome aberrations in cancer. Mutation Research-reviews in Mutation Research. ,vol. 462, pp. 247- 253 ,(2000) , 10.1016/S1383-5742(00)00006-5
Yurii Sedkov, Judith J Benes, Joseph R Berger, Karen M Riker, Sergei Tillib, Richard S Jones, Alexander Mazo, Molecular genetic analysis of the Drosophila trithorax-related gene which encodes a novel SET domain protein Mechanisms of Development. ,vol. 82, pp. 171- 179 ,(1999) , 10.1016/S0925-4773(98)00246-9