Identification of p53 as a sequence-specific DNA-binding protein

作者: S. Kern , K. Kinzler , A. Bruskin , D. Jarosz , P. Friedman

DOI: 10.1126/SCIENCE.2047879

关键词:

摘要: … ), we have suggested that a sequence-specific binding ability ofp53 might exist and be a functional target of p53 mutations (9). To identify a sequence-specific binding site, cloned DNA …

参考文章(33)
Lane Dp, Iggo R, Bartek J, Gannon J, Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines. Oncogene. ,vol. 5, pp. 893- 899 ,(1990)
Stratton Mr, Fletcher Cd, Warren W, Moss S, Clark J, Fisher C, Patterson H, Gusterson Ba, Ball A, Thomas M, Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene. Oncogene. ,vol. 5, pp. 1297- 1301 ,(1990)
J Lyons, C Sinos, A Destree, T Caiazzo, K Havican, S McKenzie, D Panicali, A Mahr, Expression of Mycobacterium tuberculosis and Mycobacterium leprae proteins by vaccinia virus. Infection and Immunity. ,vol. 58, pp. 4089- 4098 ,(1990) , 10.1128/IAI.58.12.4089-4098.1990
D. Eliyahu, D. Michalovitz, S. Eliyahu, O. Pinhasi-Kimhi, M. Oren, Wild-type p53 can inhibit oncogene-mediated focus formation. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 8763- 8767 ,(1989) , 10.1073/PNAS.86.22.8763
Ravi Misra, A. Gregory Matera, Carl W. Schmid, Mark G. Rush, Recombination mediates production of an extrachromosomal circular DNA containing a transposon-like human element, THE-1 Nucleic Acids Research. ,vol. 17, pp. 8327- 8341 ,(1989) , 10.1093/NAR/17.20.8327
T Takahashi, M. Nau, I Chiba, M. Birrer, R. Rosenberg, M Vinocour, M Levitt, H Pass, A. Gazdar, J. Minna, p53: a frequent target for genetic abnormalities in lung cancer Science. ,vol. 246, pp. 491- 494 ,(1989) , 10.1126/SCIENCE.2554494
L. M. Mulligan, G. J. Matlashewski, H. J. Scrable, W. K. Cavenee, Mechanisms of p53 loss in human sarcomas. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 5863- 5867 ,(1990) , 10.1073/PNAS.87.15.5863
P. N. Friedman, S. E. Kern, B. Vogelstein, C. Prives, Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 9275- 9279 ,(1990) , 10.1073/PNAS.87.23.9275