Hemocompatibility of EpoCore/EpoClad photoresists on COC substrate for optofluidic integrated Bragg sensors

摘要: Abstract We report on the hemocompatibility properties of EpoCore/EpoClad UV-structurable epoxy resins in combination with a TOPAS ® cyclic olefin copolymer substrate for potential application as an optofluidic biosensor chip. For comprehensive tests human blood is directly exposed to layers different chip materials up 3 h. Counts white cells, red cells and platelets well hemolysis concentration thrombin/antithrombin complex (TAT), complement fragment (C5a) heparin are determined. Our results attest high properties. Subsequently, fabrication concept integrated Bragg grating sensors suggested. gratings inscribed into rectangular EpoCore waveguides 6017 by coherent phase mask illumination. UV-structured EpoClad resist serves both waveguide cladding microfluidic channel network. In evanescent field refractive index sensing experiments sensitivities 76.9 nm/RIU maximum resolution 1.3·10 −5 achieved detecting multimode reflections.