APOL1Risk Variants Predict Histopathology and Progression to ESRD in HIV-Related Kidney Disease
作者： Derek M. Fine , Walter G. Wasser , Michelle M. Estrella , Mohamed G. Atta , Michael Kuperman
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摘要: With earlier institution of antiretroviral therapy, kidney diseases other than HIV-associated nephropathy (HIVAN) predominate in HIV-infected persons. Outcomes for these are typically worse among those infected with HIV, but the reasons this not clear. Here, we examined role APOL1 risk variants predicting renal histopathology and progression to ESRD 98 African Americans non-HIVAN disease on biopsy. We used survival analysis determine time associated genotype. Among 29 patients two alleles, majority (76%) had FSGS 10% hypertensive nephrosclerosis. In contrast, 54 one allele, 47% immune-complex GN as predominant lesion only 23% FSGS. 25 no 40% 12% 310 person-years observation, progressed ESRD. adjusted analyses, individuals alleles a nearly three-fold higher compared or zero (P=0.03). summary, data demonstrate an association between outcomes disease, suggesting possible use genotyping help guide care patients.
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