Macrophages induce differentiation of plasma cells through CXCL10/IP-10
作者： Wei Xu , HyeMee Joo , Sandra Clayton , Melissa Dullaers , Marie-Cecile Herve
DOI: 10.1084/JEM.20112142
关键词:
摘要: In tonsils, CD138+ plasma cells (PCs) are surrounded by CD163+ resident macrophages (Mϕs). We show here that human Mϕs (isolated from tonsils or generated monocytes in vitro) drive activated B to differentiate into CD138+CD38++ PCs through secreted CXCL10/IP-10 and VCAM-1 contact. IP-10 production is induced cell–derived IL-6 depends on STAT3 phosphorylation. Furthermore, amplifies the of cells, which sustains signals lead PC differentiation. IP-10–deficient mice challenged with NP-Ficoll a decreased frequency NP-specific lower titers antibodies. Thus, our results reveal novel dialog between acts as differentiation factor.
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