Emergence of canine distemper virus strains with two amino acid substitutions in the haemagglutinin protein, detected from vaccinated carnivores in North-Eastern China in 2012-2013.

作者: Jianjun Zhao , Hailing Zhang , Xue Bai , Vito Martella , Bo Hu

DOI: 10.1016/J.TVJL.2014.01.028

关键词:

摘要: A total of 16 strains canine distemper virus (CDV) were detected from vaccinated minks, foxes, and raccoon dogs in four provinces North-Eastern China between the end 2011 2013. Upon sequence analysis haemagglutinin gene comparison with wild-type CDV different species same geographical areas, two non-synonymous single nucleotide polymorphisms identified 10 strains, which led to amino acid changes at positions 542 (isoleucine asparagine) 549 (tyrosine histidine) protein coding sequence. The change residue generated a potentially novel N-glycosylation site. Masking antigenic epitopes by sugar moieties might represent mechanism for evasion neutralising antibodies reduced protection vaccination.

参考文章(11)
Karin Sekulin, Angela Hafner-Marx, Jolanta Kolodziejek, Dirk Janik, Peter Schmidt, Norbert Nowotny, Emergence of canine distemper in Bavarian wildlife associated with a specific amino acid exchange in the haemagglutinin protein Veterinary Journal. ,vol. 187, pp. 399- 401 ,(2011) , 10.1016/J.TVJL.2009.12.029
Alex J McCarthy, Marie-Anne Shaw, Simon J Goodman, Pathogen evolution and disease emergence in carnivores Proceedings of The Royal Society B: Biological Sciences. ,vol. 274, pp. 3165- 3174 ,(2007) , 10.1098/RSPB.2007.0884
Veljko M. Nikolin, Gudrun Wibbelt, Frank-Uwe F. Michler, Peter Wolf, Marion L. East, Susceptibility of carnivore hosts to strains of canine distemper virus from distinct genetic lineages Veterinary Microbiology. ,vol. 156, pp. 45- 53 ,(2012) , 10.1016/J.VETMIC.2011.10.009
Veronika von Messling, Christoph Springfeld, Patricia Devaux, Roberto Cattaneo, A Ferret Model of Canine Distemper Virus Virulence and Immunosuppression Journal of Virology. ,vol. 77, pp. 12579- 12591 ,(2003) , 10.1128/JVI.77.23.12579-12591.2003
K. Sakai, T. Yoshikawa, F. Seki, S. Fukushi, M. Tahara, N. Nagata, Y. Ami, T. Mizutani, I. Kurane, R. Yamaguchi, H. Hasegawa, M. Saijo, K. Komase, S. Morikawa, M. Takeda, Canine Distemper Virus Associated with a Lethal Outbreak in Monkeys Can Readily Adapt To Use Human Receptors Journal of Virology. ,vol. 87, pp. 7170- 7175 ,(2013) , 10.1128/JVI.03479-12
John A Lednicky, Jean Dubach, Michael J Kinsel, Thomas P Meehan, Maurizio Bocchetta, Laura L Hungerford, Nicolene A Sarich, Kelley E Witecki, Michael D Braid, Casandra Pedrak, Christiane M Houde, Genetically distant American Canine distemper virus lineages have recently caused epizootics with somewhat different characteristics in raccoons living around a large suburban zoo in the USA Virology Journal. ,vol. 1, pp. 2- 2 ,(2004) , 10.1186/1743-422X-1-2
Jian-Jun Zhao, Xi-Jun Yan, Xiu-Li Chai, Vito Martella, Guo-Liang Luo, Hai-Ling Zhang, Han Gao, Ying-Xue Liu, Xue Bai, Lei Zhang, Tao Chen, Lei Xu, Chun-Fei Zhao, Feng-Xue Wang, Xi-Qun Shao, Wei Wu, Shi-Peng Cheng, Phylogenetic analysis of the haemagglutinin gene of canine distemper virus strains detected from breeding foxes, raccoon dogs and minks in China. Veterinary Microbiology. ,vol. 140, pp. 34- 42 ,(2010) , 10.1016/J.VETMIC.2009.07.010
T. Hashiguchi, M. Kajikawa, N. Maita, M. Takeda, K. Kuroki, K. Sasaki, D. Kohda, Y. Yanagi, K. Maenaka, Crystal structure of measles virus hemagglutinin provides insight into effective vaccines. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 19535- 19540 ,(2007) , 10.1073/PNAS.0707830104
Bevan Sawatsky, Veronika von Messling, Canine Distemper Viruses Expressing a Hemagglutinin without N-Glycans Lose Virulence but Retain Immunosuppression Journal of Virology. ,vol. 84, pp. 2753- 2761 ,(2010) , 10.1128/JVI.01813-09
Veljko M. Nikolin, Klaus Osterrieder, Veronika von Messling, Heribert Hofer, Danielle Anderson, Edward Dubovi, Edgar Brunner, Marion L. East, Antagonistic Pleiotropy and Fitness Trade-Offs Reveal Specialist and Generalist Traits in Strains of Canine Distemper Virus PLoS ONE. ,vol. 7, pp. e50955- ,(2012) , 10.1371/JOURNAL.PONE.0050955