Susceptibility of carnivore hosts to strains of canine distemper virus from distinct genetic lineages

摘要: Using the complete haemagglutinin (HA) gene and partial phosphoprotein (P) we investigated genotype of canine distemper virus (CDV) strains recovered from two wildlife species in Mecklenburg-Vorpommern, Germany. Phylogenetic analyses demonstrated significant differences between raccoons Procyon lotor (family Procyonidae) obtained 2007 red foxes Vulpes vulpes Canidae) 2008. The raccoon belonged to CDV European lineage whereas fox Europe lineage. We combined our genetic sequence data with published 138 stains worldwide investigate proposed importance amino acid substitutions SLAM binding region HA protein at position 530 (G/E R/D/N) 549 (Y H) spread domestic dog-adapted other carnivores. found no evidence that was strongly affected by host species. Rather, site conserved within lineages, regardless Contrary expectation, non-dog hosts did not exhibit a bias towards predicted substitution Y549H. Wild canid were more frequently infected 549Y, pattern similar dogs. Non-canid showed either H or Y 549, although there trend 549H. Significant prevalence 549Y 549H wild non-canid suggests degree adaptation these categories host.