Predictive Biomarkers of Chemotherapy Efficacy in Colorectal Cancer: Results From the UK MRC FOCUS Trial
作者： Michael S. Braun , Susan D. Richman , Philip Quirke , Catherine Daly , Julian W. Adlard
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摘要: Purpose Candidate predictive biomarkers for irinotecan and oxaliplatin were assessed in 1,628 patients Fluorouracil, Oxaliplatin, CPT-11: Use Sequencing (FOCUS), a large randomized trial of fluorouracil alone compared with advanced colorectal cancer. Methods The candidate were: tumor immunohistochemistry MLH1/MSH2, p53, topoisomerase-1 (Topo1), excision repair cross-complementing gene 1 (ERCC1), O-6-methylguanine-DNA-methyltranserase (MGMT), cyclooxygenase 2 (COX2); germline DNA polymorphisms GSTP1, ABCB1, XRCC1, ERCC2, UGT1A1. These screened more than 750 interaction benefit from or oxaliplatin; two markers (Topo1 MLH1/MSH2) met criteria to be taken forward analysis the full population. Primary end points progression-free survival (PFS) overall survival. Results One thousand three hundred thirteen (81%) assessable Topo1 i...
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