Evaluation of the In Vitro Activity of Ceftazidime-Avibactam and Ceftolozane-Tazobactam against Meropenem-Resistant Pseudomonas aeruginosa Isolates.
作者： Deanna J. Buehrle , Ryan K. Shields , Liang Chen , Binghua Hao , Ellen G. Press
DOI: 10.1128/AAC.02969-15
关键词:
摘要: We compared ceftazidime-avibactam, ceftolozane-tazobactam, ceftazidime, cefepime, and piperacillin-tazobactam MICs for 38 meropenem-resistant Pseudomonas aeruginosa isolates. No isolates harbored carbapenemases; 74% were oprD mutants. Ceftazidime-avibactam ceftolozane-tazobactam active against 92% of the isolates, including 80% that resistant to all three β-lactams. Forty-three percent ceftazidime-avibactam-susceptible 6% ceftolozane-tazobactam-susceptible exhibited at respective breakpoints. Ceftolozane-tazobactam ceftazidime-avibactam are therapeutic options P. infections should be used judiciously preserve activity.
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