Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in rats.
作者： G CASADESUS , B SHUKITTHALE , H STELLWAGEN , M SMITH , B RABIN
DOI: 10.1016/J.EXGER.2004.09.007
关键词:
摘要: Exposure to particles of high energy and charge can disrupt the neuronal systems as well motor cognitive behaviors mediated by these in a similar fashion that seen during aging process. In hippocampus, adult neurogenesis is affected both irradiation with ionizing particles. Likewise, maturation newly formed cells this region measured PSA-NCAM expression also altered The present study was designed investigate effects 2.5 Gy 1 GeV/n 56Fe on using nuclear proliferation marker 5-bromodeoxyuridine (BrdU dentate gyrus rats exposed whole-body or simply placed chamber without being irradiated. All subjects (n=10) were sacrificed 28 days after last BrdU injection (50 mg/kg X 3 days) their brains processed for immunohistochemistry. Results illustrate decrease number BrdU-positive different distribution irradiated animals. Additionally, show decreased levels expression. These changes are consistent those found aged indicating heavy-particle an adequate model aging.
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