摘要: The potential for exploration of peptide nucleic acid (PNA) as an experimental and therapeutic regulator gene expression has been hampered by a poor delivery lack site-specific targeting. In the present study, we have developed efficient strategy nuclear PNA combining cationically charged PNA-peptide conjugates photochemical internalization (PCI) technology. When using S100A4 model system, consistent downregulation to around 10% remaining protein signal was obtained in three selected cell lines. Furthermore, dose-dependent time-dependent inhibition demonstrated. A main benefit proposed is possibility
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