Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL–transformed hematopoietic cell lines

作者: Ellen Weisberg , James D. Griffin

DOI: 10.1182/BLOOD.V95.11.3498

关键词:

摘要: … of 2 BCR/ABL–positive cell lines that have developed partial resistance to STI571. BCR/ABL–… have an increase in Bcr/Abl messenger RNA, amplification of the Bcr/Abl transgene, and a …

参考文章(35)
Elisabeth W. H. M. Eijdems, Marcel de Haas, José M. Coco-Martin, Cecile P. E. Ottenheim, Guido J. R. Zaman, Hans G. Dauwerse, Martijn H. Breuning, Peter R. Twentyman, Piet Borst, Frank Baas, Mechanisms of MRP over-expression in four human lung-cancer cell lines and analysis of the MRP amplicon International Journal of Cancer. ,vol. 60, pp. 676- 684 ,(1995) , 10.1002/IJC.2910600518
M.Tien Kuo, Subrata Sen, Walter N Hittelman, T.C Hsu, Chromosomal Fragile Sites and DNA Amplification in Drug-resistant Cells Biochemical Pharmacology. ,vol. 56, pp. 7- 13 ,(1998) , 10.1016/S0006-2952(98)00040-9
Brian J. Druker, Shu Tamura, Elisabeth Buchdunger, Sayuri Ohno, Gerald M. Segal, Shane Fanning, Jürg Zimmermann, Nicholas B. Lydon, Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nature Medicine. ,vol. 2, pp. 561- 566 ,(1996) , 10.1038/NM0596-561
P. Yaish, A. Gazit, C. Gilon, A. Levitzki, Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors Science. ,vol. 242, pp. 933- 935 ,(1988) , 10.1126/SCIENCE.3263702
Arnaud Coquelle, Eva Pipiras, Franck Toledo, Gérard Buttin, Michelle Debatisse, Expression of Fragile Sites Triggers Intrachromosomal Mammalian Gene Amplification and Sets Boundaries to Early Amplicons Cell. ,vol. 89, pp. 215- 225 ,(1997) , 10.1016/S0092-8674(00)80201-9
T. Lugo, A. Pendergast, A. Muller, O. Witte, Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science. ,vol. 247, pp. 1079- 1082 ,(1990) , 10.1126/SCIENCE.2408149
G. Q. Daley, D. Baltimore, Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 9312- 9316 ,(1988) , 10.1073/PNAS.85.23.9312
Nora Heisterkamp, Kees Stam, John Groffen, Annelies de Klein, Gerard Grosveld, Structural organization of the bcr gene and its role in the Ph' translocation. Nature. ,vol. 315, pp. 758- 761 ,(1985) , 10.1038/315758A0
Y Ben-Neriah, G. Daley, A. Mes-Masson, O. Witte, D Baltimore, The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene. Science. ,vol. 233, pp. 212- 214 ,(1986) , 10.1126/SCIENCE.3460176
Arnaud Coquelle, Franck Toledo, Sabine Stern, Anne Bieth, Michelle Debatisse, A New Role for Hypoxia in Tumor Progression: Induction of Fragile Site Triggering Genomic Rearrangements and Formation of Complex DMs and HSRs Molecular Cell. ,vol. 2, pp. 259- 265 ,(1998) , 10.1016/S1097-2765(00)80137-9