Theranostic Impact of NG2/CSPG4 Proteoglycan in Cancer

摘要: NG2/CSPG4 is an unusual cell-membrane integral proteoglycan widely recognized to be a prognostic factor, valuable tool for ex vivo and non-invasive molecular diagnostics and, by virtue of its tight association with malignancy, tantalizing therapeutic target in several tumour types. Although the biology behind involvement cancer progression needs better understood, implementation routine clinical practice attainable has potential contribute improved individualized management patients. In this context, polymorphic nature seems particularly effort standardize informative diagnostic procedures consolidate forcible immunotherapeutic treatment strategies. We discuss here underpinnings highlight benefits taking advantage intra-tumour inter-patient variability regulation expression. envision that may effectively exploited interventions aimed at averting resistance therapy agents interfering secondary lesion formation and/or recurrence.