NG2 proteoglycan promotes angiogenesis-dependent tumor growth in CNS by sequestering angiostatin

摘要: During embryogenesis, the NG2 proteoglycan is expressed on immature capillary vessels, but as vessels mature they lose this expression. up-regulated in high-grade gliomas, it not clear to what extent contributes malignant progression. Using a combination of high spatial and temporal resolution functional magnetic resonance imaging histopathological analyses, we show here that overexpression increases tumor initiation growth rates, neovascularization, cellular proliferation, which predisposes poorer survival outcome. By confocal microscopy cDNA gene array expression profiles, also tumors express lower levels hypoxia inducible factor-1α, vascular endothelial factor, endogenous angiostatin vivo compared with wild-type tumors. Moreover, demonstrate NG2-positive cells bind, internalize, coimmunoprecipitate angiostatin. These results indicate unique role for regulating transition from small, poorly vascularized large, highly gliomas situ by sequestering