Behavioral Signs of Chronic Back Pain in the SPARC-Null Mouse

摘要: Study Design. Secreted Protein, Acidic, and Rich in Cysteine (SPARC)-null mice were examined for behavioral signs of chronic low back and/or radicular pain. Objective.To assess SPARC-null as an animal model pain caused by degenerative disc disease. Summary Background Data. Degeneration intervertebral discs is a major cause adicular humans. Inactivation the SPARC gene results premature degeneration. The effect degeneration on measures has not been evaluated this model. Methods. Cohorts young old (3 6-12 months, respectively) wild-type control screened indices radiating Sensitivity to mechanical, cold heat stimuli, locomotor impairment, movement-evoked hypersensitivity determined. Animals challenged with 3 analgesic agents different mechanisms: morphine, dexamethasone, gabapentin. Results. showed discomfort early months age. Hypersensitivity stimuli both lower hindpaws developed increasing had normal sensitivity tactile skills impaired. was reversed but dexamethasone or Conclusion. display consistent that we attribute We hypothesize mouse useful due