Δ9-Tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion
作者： Yasuko Sakurai , Hisashi Ohta , Takao Shimazoe , Yasufumi Kataoka , Michihiro Fujiwara
DOI: 10.1016/0024-3205(85)90569-7
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摘要: Abstract The present study was designed to examine the influence of Δ 9 -tetrahydrocannabinol (THC) on central dopaminergic system using circling behavior. THC 5 mg/kg i.p. produced ipsilateral in rats with unilateral nigral lesion by 6-hydroxydopamine. THC-induced ispilateral completely antagonized 0.2 haloperidol. These findings suggest that may cause a presynaptic stimulation nigrostriatal neurons.
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