In Vivo Delivery of Glial Cell-Derived Neurotrophic Factor Across the Blood-Brain Barrier by Gene Transfer into Brain Capillary Endothelial Cells

作者: Chen Jiang , Noriko Koyabu , Yoshikazu Yonemitsu , Takao Shimazoe , Shigenori Watanabe

DOI: 10.1089/104303403322168019

关键词: Neurotrophic factorsNeurogliaGlial cell line-derived neurotrophic factorEndothelial stem cellBlood–brain barrierGene productMolecular biologyBiologyTransfectionCell culture

摘要: … of temporary blood-brain barrie (… deliver therapeutic peptides or proteins after transfection with the appropriate exogenous gene. In this study, we established a novel method to deliver a …

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