Continuous versus Conventional Infusion of Amphotericin B Deoxycholate: A Meta-Analysis

摘要: Background Treatment with Amphotericin B (AmB) deoxycholate, which is still used widely, particularly in low-resource countries, has been challenged due to nephrotoxicity. We sought study whether continuous infusion of AmB deoxycholate reduces nephrotoxicity retaining, however, the effectiveness drug. Methods PubMed and Scopus databases were systematically searched identify studies comparing outcomes patients receiving 24-h (“continuous group”) those 2–6-h (“conventional group”). Nephrotoxicity all-cause mortality primary review, while treatment failure was secondary outcome. Results Five met inclusion criteria; one randomized controlled trial, two prospective cohort studies, retrospective studies. The majority neutropenic an underlying hematologic malignancy. All 5 (392 patients) provided data regarding development A non-significant trend towards lower observed for compared conventional [RR = 0.61 (95% CI 0.36, 1.02)]. Four (365 mortality; no relevant difference detected between 0.81 1.83)]. Data on methods administration insufficient meaningful conclusions. Conclusion The available evidence from mainly non-randomized suggests that might offer advantage over nephrotoxicity, without compromising patient survival. Further are needed investigate this issue.