Early Therapy of Vertical Human Immunodeficiency Virus Type 1 (HIV-1) Infection: Control of Viral Replication and Absence of Persistent HIV-1-Specific Immune Responses
作者： Katherine Luzuriaga , Margaret McManus , Michelle Catalina , Shane Mayack , Mark Sharkey
DOI: 10.1128/JVI.74.15.6984-6991.2000
关键词:
摘要: Studies of potent antiretroviral combination regimens were undertaken in young infants to evaluate the potential for long-term suppression viral replication and immune consequences such therapies. Early therapy led a loss plasma viremia, cultivable virus, labile extrachromosomal intermediates. Despite preservation function, persistent human immunodeficiency type 1 (HIV-1)-specific responses not detected most infants. The absence detectable, persisting HIV-1-infected treated early contrasts with what is typically seen adults who are early. These results consistent notion that allows replication.
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A Böyum, Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 97, pp. 77- 89 ,(1968)
Daar Es, Virology and immunology of acute HIV type 1 infection AIDS Research and Human Retroviruses. ,vol. 14, ,(1998)
Spyros A. Kalams, Kelly E. Hartman, Katherine Luzuriaga, Bruce D. Walker, Otto O. Yang, Norman G. Jones, Philip J. R. Goulder, Christian Brander, Persistent HIV-1-specific CTL clonal expansion despite high viral burden post in utero HIV-1 infection Journal of Immunology. ,vol. 162, pp. 4796- 4800 ,(1999)
Christine J. Pitcher, Claudia Quittner, Dolores M. Peterson, Mark Connors, Richard A. Koup, Vernon C. Maino, Louis J. Picker, HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression. Nature Medicine. ,vol. 5, pp. 518- 525 ,(1999) , 10.1038/8400
Koen K. A. van Rompay, Peter J. Dailey, Ross P. Tarara, Don R. Canfield, Nancy L. Aguirre, Julie M. Cherrington, Patrick D. Lamy, Norbert Bischofberger, Niels C. Pedersen, Marta L. Marthas, Early Short-Term 9-[2-(R)-(Phosphonomethoxy)Propyl]Adenine Treatment Favorably Alters the Subsequent Disease Course in Simian Immunodeficiency Virus-Infected Newborn Rhesus Macaques Journal of Virology. ,vol. 73, pp. 2947- 2955 ,(1999) , 10.1128/JVI.73.4.2947-2955.1999
D L Panicali, K Luzuriaga, J L Sullivan, A Hereema, D Holmes, J Wong, HIV-1-specific cytotoxic T lymphocyte responses in the first year of life. Journal of Immunology. ,vol. 154, pp. 433- 443 ,(1995)
Patricia M. Garcia, Leslie A. Kalish, Jane Pitt, Howard Minkoff, Thomas C. Quinn, Sandra K. Burchett, Janet Kornegay, Brooks Jackson, John Moye, Celine Hanson, Carmen Zorrilla, Judy F. Lew, Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission The New England Journal of Medicine. ,vol. 341, pp. 394- 402 ,(1999) , 10.1056/NEJM199908053410602
D D Ho, Perspectives series: host/pathogen interactions. Dynamics of HIV-1 replication in vivo. Journal of Clinical Investigation. ,vol. 99, pp. 2565- 2567 ,(1997) , 10.1172/JCI119443
D. N. Garboczi, D. T. Hung, D. C. Wiley, HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 3429- 3433 ,(1992) , 10.1073/PNAS.89.8.3429
C B Wilson, J Westall, L Johnston, D B Lewis, S K Dower, A R Alpert, Decreased production of interferon-gamma by human neonatal cells. Intrinsic and regulatory deficiencies. Journal of Clinical Investigation. ,vol. 77, pp. 860- 867 ,(1986) , 10.1172/JCI112383