[A case of HIV-1 infection that showed Western blot analysis for HIV-1 negative after antiretroviral therapy].

摘要: Western blot (WB) is the most widely accepted confirmatory assay for detecting antibodies to human immunodeficiency virus 1 (HIV-1). We report case of an HIV-1 patient whose WB was negative over two years. A 41-year-old Japanese man with Pneumocystis pneumonia (PCP) and pulmonary tuberculosis referred in March 2005 found have positive ELISA HIV RNA PCR, but only bands, at gp160 p18, no HIV-2 band. The CD4 count 37/microL, total immunoglobulin, IgG, IgM, IgG subclasses were normal. treated PCP tuberculosis, then underwent antiretroviral therapy. He had taken short-terms steroids treat a drug allergy immune reconstitution syndrome. Six months later, his serological tests DNA PCR showed recovered gradually, exceeded 350/microL years remained negative. Lymphoproliferative assays interferon y expression against HIV-pl7, p24, p41 studied compared those other infected patients. Our response p17 or p24 weak p41. Other patients HIV-antigens, therapy histories steroid use responded more weakly than neither. These findings show that HIV-specific lymphocytes decline treatment within early infection. It therefore important interpret carefully such as ours.