Inhibition of HIV-1-specific T-cells and increase of viral load during immunosuppressive treatment in an HIV-1 infected patient with Chlamydia trachomatis induced arthritis.

摘要: Abstract Background: Studies in HIV-1 infected long-term non-progressors could demonstrate a strong HIV-1-specific CTL response, but it is difficult to prove that this response actually the cause of efficient control and not consequence low replication these patients. Objective: immunity viral patients undergoing immunosuppressive therapy provide important opportunities understand role T-cells. Results: In report we describe an HLA B27 positive patient with normal CD4 counts load 200 copies/ml without antiretroviral who exhibited very response. He had be treated steroids, NSAIDS hydroxchloroquine because severe inflammatory reactive arthritis triggered by acute Chlamydia trachomatis infection. Analysis specific T-cells γ-IFN-ELISPOT revealed high frequency gag-specific both blood synovial fluid, whereas CD4-cells detected only peripheral blood. Further analysis were predominantly targeting B27-restricted epitope KRWIILGLNK (KK10). Immunosuppressive prednisone was associated moderate increase viremia decrease number γ-IFN production KK10-specific indicating inhibition function contributed load. Conclusions: This study suggesting play HIV-1, at least patient. Inhibition may enhance replication. addition, for first time migration into fluid.