What determines the switch between atrophic and neovascular forms of age related macular degeneration? - the role of BMP4 induced senescence.
作者： DanHong Zhu , Xuemei Deng , Jing Xu , David R Hinton
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摘要: Age-related macular degeneration (AMD), the leading cause of blindness in elderly, targets retinal pigment epithelium (RPE), a monolayer cells at back eye. As AMD progresses, it can develop into two distinct forms late AMD: "dry," atrophic AMD, characterized by RPE senescence and geographic loss, "wet," neovascular activation with abnormal growth choroidal vessels. The genetic molecular pathways that lead to these diverse phenotypes are currently under investigation. We have found bone morphogenetic protein-4 (BMP4) is differentially expressed AMD. In BMP4 highly RPE, mediates oxidative stress induced senescencein vitro via Smad p38 pathways. contrast, lesions, expression low, possibly result local pro-inflammatory mediators. Thus, may be involved switch determining which phenotypic pathway taken progression
s3-us-west-1.amazonaws.com 参考文章(36)
Françoise Trousse, Pilar Esteve, Paola Bovolenta, Bmp4 mediates apoptotic cell death in the developing chick eye. The Journal of Neuroscience. ,vol. 21, pp. 1292- 1301 ,(2001) , 10.1523/JNEUROSCI.21-04-01292.2001
Lars Zender, K. Lenhard Rudolph, Keeping your senescent cells under control Aging. ,vol. 1, pp. 438- 441 ,(2009) , 10.18632/AGING.100046
Michael L Klein, Frederick L Ferris III, Jane Armstrong, Thomas S Hwang, Emily Y Chew, Susan B Bressler, Suresh R Chandra, AREDS Research Group, Retinal precursors and the development of geographic atrophy in age-related macular degeneration. Ophthalmology. ,vol. 115, pp. 1026- 1031 ,(2008) , 10.1016/J.OPHTHA.2007.08.030
T. Yoshimura, K. Matsushima, S. Tanaka, E. A. Robinson, E. Appella, J. J. Oppenheim, E. J. Leonard, Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 9233- 9237 ,(1987) , 10.1073/PNAS.84.24.9233
Iwona Malgorzata Goczalik, Maik Raap, Michael Weick, Ivan Milenkovic, Jördis Heidmann, Volker Enzmann, Peter Wiedemann, Andreas Reichenbach, Mike Francke, The activation of IL-8 receptors in cultured guinea pig Müller glial cells is modified by signals from retinal pigment epithelium Journal of Neuroimmunology. ,vol. 161, pp. 49- 60 ,(2005) , 10.1016/J.JNEUROIM.2004.12.004
Zoya N. Demidenko, Svetlana G. Zubova, Elena I. Bukreeva, Valery A. Pospelov, Tatiana V. Pospelova, Mikhail V Blagosklonny, Rapamycin decelerates cellular senescence Cell Cycle. ,vol. 8, pp. 1888- 1895 ,(2009) , 10.4161/CC.8.12.8606
Alice L. Yu, Rudolf Fuchshofer, Daniel Kook, Anselm Kampik, Hans Bloemendal, Ulrich Welge-Lu¨ssen, Subtoxic Oxidative Stress Induces Senescence in Retinal Pigment Epithelial Cells via TGF-β Release Investigative Ophthalmology & Visual Science. ,vol. 50, pp. 926- 935 ,(2009) , 10.1167/IOVS.07-1003
K. Takebayashi-Suzuki, Interplay between the tumor suppressor p53 and TGF beta signaling shapes embryonic body axes in Xenopus. Development. ,vol. 130, pp. 3929- 3939 ,(2003) , 10.1242/DEV.00615
Sandra L Harris, Arnold J Levine, The p53 pathway: positive and negative feedback loops Oncogene. ,vol. 24, pp. 2899- 2908 ,(2005) , 10.1038/SJ.ONC.1208615
Jean-Philippe Coppé, Christopher K Patil, Francis Rodier, Yu Sun, Denise P Muñoz, Joshua Goldstein, Peter S Nelson, Pierre-Yves Desprez, Judith Campisi, Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor PLOS Biology. ,vol. 6, pp. 2853- 2868 ,(2008) , 10.1371/JOURNAL.PBIO.0060301