Global Transmission Dynamics of Measles in the Measles Elimination Era

摘要: Although there have been many epidemiological reports of the inter-country transmission measles, systematic analysis global dynamics measles virus (MV) is limited. In this study, we applied phylogeographic to characterize MV using large-scale genetic sequence data (obtained for 7456 sequences) from 115 countries between 1954 and 2015. These analyses reveal spatial temporal characteristics virus, especially in Australia, China, India, Japan, UK, USA period since 1990. The frequently observed, not only within same region but also among distant visited areas. Frequencies export measles-endemic countries, such as Japan are high decreasing, while frequencies where no longer endemic, USA, low slightly increasing. world heading toward eradication, disease still transmitted regionally globally. Our reveals that wherein endemic those having eliminated (apart occasional outbreaks) both remain a source elimination era. It therefore crucial maintain vigilance efforts monitor eradicate