Action of modafinil through histaminergic and orexinergic neurons.

摘要: Modafinil is a wake-promoting drug used for the treatment of excessive daytime sleepiness due to narcolepsy as well associated with obstructive sleep apnea and shift work disorder. Although effect modafinil expressed through dopaminergic norepinephrinergic systems similar that classical psychostimulants, mechanism action distinct from those compounds in terms involvement histaminergic orexinergic systems. activates system an indirect manner, presumably via attenuation inhibitory GABAergic input neurons. The controls arousal system, modafinil-induced increment histamine release abolished orexin neuron-ablated mice, suggesting increases tone Clinical experimental investigations have suggested less importance modafinil, but considered be involved alertness or synaptic plasticity.