Original Article Melanoma patient derived xenografts acquire distinct Vemurafenib resistance mechanisms

作者: Brian J Nickoloff , Nicholas S Duesbery , David M Cherba , Noel R Monks , Karl J Dykema

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摘要: Variable clinical responses, tumor heterogeneity, and drug resistance reduce long-term survival outcomes for metastatic melanoma patients. To guide accelerate development, we characterized responses five patient derived xenograft models treated with Vemurafenib . Three BRAF

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