Progression of cutaneous melanoma: implications for treatment

摘要: The survival rates of melanoma, like any type cancer, become worse with advancing stage. Spectrum theory is most consistent the progression melanoma from primary site to in-transit locations, regional or sentinel lymph nodes and beyond distant sites. Therefore, early diagnosis surgical treatment before its spread effective treatment. Recently, new approaches have revolutionized melanoma. Genomic profiling sequencing will form basis for molecular taxonomy more accurate subgrouping patients in future. New insights mechanisms metastasis are summarized this review article. Sentinel node biopsy has a standard care staging without need morbid complete dissection. With recent developments biology genomics, novel targeted therapy being developed through clinical trials.