Glycosaminoglycan content of knee cartilage following posterior cruciate ligament rupture demonstrated by delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC). A case report.

摘要: Following joint trauma and during the early stages of cartilage degeneration, typical changes become apparent in tissue structure composition, including loss glycosaminoglycan1,2. These often are not on conventional magnetic resonance imaging or visible at arthroscopy, thereby precluding diagnosis. Delayed gadolinium-enhanced cartilage, dGEMRIC, is an emerging vivo method for assessment biochemical composition articular provides a surrogate measure glycosaminoglycan content3,4. When injected intravenously, anionic contrast agent gadolinium diethylene triamine penta-acetic acid (Gd-DTPA2–) penetrates both from synovial surface subchondral bone3,5. Given sufficient time, distributes inversely to fixed negative charge associated with content accordance Donnan principle equilibrium. Gd-DTPA2-therefore relatively higher concentrations regions low glycosaminoglycan, vice versa. Gd-DTPA2-has concentration-dependent effect parameter T1; therefore, T1 presence Gd-DTPA2– (T1Gd) reflects Gd-DTPA2–concentration and, hence, concentration. We present case patient (one authors [A.A.Y.]) who sustained injury posterior cruciate ligament knee while enrolled as “normal” control subject dGEMRIC study knee. This incidental occurrence provided us unique opportunity visualize temporal spatial that occur biochemistry following acute rupture. Athirty-year-old man was involved motor-vehicle accident which he direct blow anterior aspect proximal portion right tibia 90° flexion (a “dashboard” type …