Effects of sunitinib on tumor hemodynamics and delivery of chemotherapy

摘要: Current clinical protocols favor a combination of antiangiogenic/antivascular compounds with classical chemotherapy. However, it remains unclear to what extent an therapy influences the delivery Therefore, aim present study was characterize effects antiangiogenic tyrosine kinase inhibitor sunitinib on tumor microhemodynamics and SF126 cells were implanted subcutaneously into nude mice analyzed repeatedly by intravital microscopy. Treatment initiated 7 days after implantation. To assess vasculature hemodynamics, we total functional vessel densities, microvascular diameter, blood flow rate. chemotherapy, autofluorescent doxorubicin systemically administered its vascular tissue quantified. Histological analysis included endothelial cell proliferation, pericyte coverage vessels, proliferation. Sunitinib significantly suppressed growth both antivascular effects. number vessels escaped therapy. Interestingly, in these surviving treatment resulted increased rate resulting improved chemotherapy via vessels. Besides potent efficacy, results that escape leading These provide basis for potential chemosensitizing effect sunitinib.