Environmentally oriented models and methods for the evaluation of drug × drug interaction effects.

摘要: This detailed review compares known and widely used methods for drug interaction estimation, some of which now have historical significance. Pharmaceutical application has been noted as far back several thousand years ago. Relatively late in the 20th century, however, researchers became aware that their fate metabolism, still remain a great challenge environmental analysts risk assessors. For patient's well-being, treatment based on mixing drugs to be effective should not cause any side effects (or significant impact health mortality). Therefore, it is important carefully examine both individually combinations. It also stated form/way entering living organism importance well age place trophic system order eliminate harmful dosages case infants’ accidental intoxication.