Helicobacter pylori infection generates genetic instability in gastric cells

摘要: Abstract The discovery that Helicobacter pylori is associated with gastric cancer has led to numerous studies investigate the mechanisms by which H . induces carcinogenesis. Gastric shows genetic instability both in nuclear and mitochondrial DNA, besides impairment of important DNA repair pathways. As such, this review highlights consequences infection on integrity host cells. By down-regulating major pathways, potential generate mutations. In addition, can induce direct changes host, such as oxidative damage, methylation, chromosomal instability, microsatellite Interestingly, generates DNA. Based reviewed literature we conclude promotes carcinogenesis at least three different mechanisms: (1) a combination increased endogenous damage decreased activities, (2) induction mutations (3) generation transient mutator phenotype genome.