Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells1,2 1Guest Editor: Miral Dizdaroglu 2This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the journal.

摘要: Exposure to exogenous and endogenous sources cause oxidative damage cellular macromolecules, including DNA. This results in gradual accumulation of DNA base lesions, order maintain genomic stability we must have effective systems repair this kind damage. The lesions is most dramatic the mitochondrial DNA, may dysfunction loss energy production. Base excision (BER) major pathway that removes while know much about its mechanism nuclear little yet known mitochondria. While BER decreases with age, increase age. not enough prevent Accumulation age be underlying for age-associated diseases cancer.