Efficacy of capecitabine versus 5-fluorouracil in colorectal and gastric cancers: a meta-analysis of individual data from 6171 patients

摘要: Background: To compare the effects of oral capecitabine-containing chemotherapy regimens with i.v. 5-fluorouracil (5-FU)-containing on overall survival in patients gastrointestinal cancers. Methods: A meta-analysis, based individual patient data from six randomised non-inferiority trials, was carried out at request regulatory authorities to single-agent capecitabine or versus matched 5-FU-based terms stage III colon, metastatic colorectal advanced gastric cancer. Results: Data a total 6171 colon cancer (n = 1987), 3868) 316) were included. 3097 treated and 3074 5-FU-containing chemotherapy. The unadjusted hazard ratio for 0.94 (95% confidence interval 0.89-1.00; P 0.0489). Conclusions: Oral is least equivalent 5-FU Capecitabine can be used interchangeably these populations.