作者: Alex Fogli Iseppe , Angela Pignatelli , Ottorino Belluzzi
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摘要: Within the olfactory bulb (OB), periglomerular (PG) cells consist of various types interneurons, generally classified by their chemical properties such as neurotransmitter and calcium binding proteins. Calretinin (CR) characterizes morphologically functionally more numerous one less known subpopulation PG in OB. Using transgenic mice expressing eGFP under CR promoter, we have tried to obtain first functional characterization these cells. Electrophysiological recordings were made using patch-clamp technique thin slices. ion substitution methods specific blockers, dissected main voltage-dependent conductances present, obtaining a complete kinetic description for each them. The peculiar property from electrophysiological point view is presence only single K-current, IA - there no trace delayed rectifier or Ca-dependent K-current. Other currents identified, isolated fully characterised are two inward currents, fast sodium current small L-type current, an rectifier, h-type cationic current. As consequence complement present cells, particular absence delayed-rectifier potassium interesting properties. First, response prolonged depolarisations, after inactivation A-current, behave purely ohmic elements, showing outward rectification. Second, studied can respond with action potential excitatory inputs; since they send inhibitory synapses projection neurones, seem be designed inhibit responses neurones isolated, random signals, losing vetoing effect structured, repetitive result odour detection. We propose that possible role rather untalkative interneurons intense exchange messages within might improving signal-to-noise ratio stages information processing.