The role of mitochondria in the oncogenic signal transduction

摘要: Abstract Mitochondria are intracellular organelles thought to have evolved from an alphaproteobacterium engulfed by the ancestor of eukaryotic cell, archeon, two billion years ago. Although mitochondria frequently recognised as “power plant” function these go beyond simple generation ATP. In fact, mounting evidence suggests that involved in several cellular processes, regulation cell death signal transduction. Given this important role physiology, mitochondrial dysfunction has been associated with human diseases including cancer. Importantly, recent is directly regulated oncogenes and tumour suppressors. However, consequences deregulation formation still unclear. review, I propose play a pivotal shaping oncogenic signalling cascade dysfunction, some circumstances, required step for cancer transformation.