Residual economic burden of Streptococcus pneumoniae- and nontypeable Haemophilus influenzae- associated disease following vaccination with PCV-7: A multicountry analysis

摘要: This paper estimates the annual direct medical and caregiver costs of Streptococcus pneumoniae (Sp) nontypeable Haemophilus influenzae (NTHi)-associated diseases in children younger than 10 years Canada, Germany, Mexico, Norway after vaccination with 7-valent pneumococcal conjugate vaccine (PCV-7). Per-episode for treating Sp- NTHi-associated were summarised from literature three countries, a Delphi panel was used to estimate resource use per-episode Mexico. or inflated 2008 local currency converted United States (US) dollars using purchasing power parities. The analysis 1 year; therefore, not discounted. resulted current national $179-$260 million ($5.43-$7.89 per capita) $290-$435 ($3.53-$5.29 $277-$432 ($2.59-$4.05 $20-$28 ($4.35-$6.17 Norway. Although acute otitis media (AOM) associated lowest per-case costs, it accounted between 45% 88% 67% 96% diseases. continue result substantial despite PCV-7 programs.