Immunological risks of minimization strategies

摘要: Summary During the past 10 years, minimization strategies have been legitimately initiated to decrease many toxicities of calcineurin inhibitors, especially nephrotoxicity which was considered be responsible for majority graft losses. Even though CNI-induced is undeniable, we learned in 10 years that DSAs detected with solid-phase assays are excellent prognostic biomarkers kidney transplantation (and other organ transplantations as well) and chronic antibody-mediated rejection has become leading cause loss. In this review, will focus on immunological risks linked various aiming at decreasing CNI doses either time or later course follow-up. Some these interventions associated an increase acute cellular rates but also improvement renal function. The effects occurrence de novo donor-specific antibodies still under-reported. We currently missing long-term data appreciate influence patient survival. This then leads a cautious attitude regarding reducing immunosuppression.