Flow cytofluorometric analysis of serial biopsies of tumours of the uterine cervix

作者: J.E.D. Dyson , C.A.F. Joslin , P. Quirke , C.C. Bird

DOI: 10.1016/0277-5379(84)90255-4

关键词:

摘要: The technique of flow cytofluorometry has been employed to assess, by means cell suspensions prepared from serial biopsies, the radioresponsiveness tumours uterine cervix. This enables DNA profiles and content proliferating cells be determined prior treatment during external beam intracavitary therapy. Results show that elimination hyperdiploid hypertetraploid reduction in fraction can readily monitored this method information, quickly available treatment, may assist estimating tumour possible prognosis for patient. Dose fractionation schedules also adjusted according response Our results, however, no relationship between histopathological classification a (WHO) its ploidy state. advanced stages disease (II III) do, an increased biopsies.

参考文章(15)
G.G. Herman, S.B. Gusberg, Radiosensitivity testing of cervix cancer by the test dose technique. American Journal of Roentgenology. ,vol. 87, pp. 60- 68 ,(1962)
S.B. Gusberg, Grace G. Herman, Radiosensitivity and virulence factors in cervical cancer. Individualization of treatment. American Journal of Obstetrics and Gynecology. ,vol. 100, pp. 627- 639 ,(1968) , 10.1016/S0002-9378(15)33388-3
Anneke M. J. Van Driel-Kulker, Johan S. Ploem, The Use of LEYTAS in Analytical and Quantitative Cytology IEEE Transactions on Biomedical Engineering. ,vol. 29, pp. 92- 100 ,(1982) , 10.1109/TBME.1982.325014
Barthel Barlogie, Dennis A. Johnston, Leslie Smallwood, Martin N. Raber, Anne Marie Maddox, Kean Latreille, Douglas E. Swartzendruber, Benjamin Drewinko, Prognostic implications of ploidy and proliferative activity in human solid tumors. Cancer Genetics and Cytogenetics. ,vol. 6, pp. 17- 28 ,(1982) , 10.1016/0165-4608(82)90017-6
Alfred Glucksmann, Stanley Way, Cora P. Cherry, THE TEN-YEAR RESULTS OF INDIVIDUALIZED TREATMENT OF CARCINOMA OF THE CERVIX BASED ON THE ANALYSIS OF SERIAL BIOPSIES BJOG: An International Journal of Obstetrics and Gynaecology. ,vol. 71, pp. 198- 201 ,(1964) , 10.1111/J.1471-0528.1964.TB04266.X
W A Linden, K Ochlich, H Baisch, K U Scholz, H J Mauss, H E Stegner, D S Joshi, C T Wu, I Koprowska, C Nicolini, Flow cytometric prescreening of cervical smears. Journal of Histochemistry and Cytochemistry. ,vol. 27, pp. 529- 535 ,(1979) , 10.1177/27.1.86573
A. Jakobsen, P. Baek Kristensen, H. Kvist Poulsen, Flow cytometric classification of biopsy specimens from cervical intraepithelial neoplasia Cytometry. ,vol. 4, pp. 166- 169 ,(1983) , 10.1002/CYTO.990040210
M Stöhr, K Goerttler, The Heidelberg flow analyzer and sorter (HEIFAS) approach on the prescreening of uterine cancer. Journal of Histochemistry and Cytochemistry. ,vol. 27, pp. 564- 566 ,(1979) , 10.1177/27.1.86578
M C Habbersett, M Shapiro, B Bunnag, I Nishiya, C Herman, Quantitative Analysis of Flow Microfluorometric Data for Screening Gynecologic Cytology Specimens Journal of Histochemistry and Cytochemistry. ,vol. 27, pp. 536- 544 ,(1979) , 10.1177/27.1.86574