Key regulatory transcription factors involved in placental trophoblast development--a review.

摘要: Specification of the trophoblast cell lineage comprising outermost epithelial layer blastocyst occurs early in development and is a prerequisite for implantation embryo subsequent formation placenta, multifunctional organ which indispensable proper fetus. Trophoblast stem cells placenta give rise to distinct highly differentiated subtypes build functional units organ. These specialized assure anchorage mother, establishing vascular connection transporting nutrients gases expression hormones that are required successful progression pregnancy. Developmental processes occur spatially temporally organized manner. Despite these facts, little known on key regulatory factors commit differentiate humans. Recent studies mice, however, provided evidence various cell-type specific transcription play crucial roles developmental programme trophoblast. In this review we will focus function major murine trophoblast/placental discuss potential role their homologues human system.