Exploring the feasibility and synergistic value of the One Health approach in clinical research: protocol for a prospective observational study of diagnostic pathways in human and canine patients with suspected urinary tract infection

摘要: The One Health approach is emerging in response to the development of bacterial resistance. To best our knowledge, possibility use this a clinical context has not yet been explored. Thus, paper, we report procedures implement prospective observational study diagnostic pathways human and canine patients with suspected urinary tract infection as means assess feasibility synergistic value setting up research projects interventions. A will compare different (i.e., 16 possible combinations tools) gold standard veterinary primary care practice Denmark. Fifty practices 100 clinics each consecutively include 20 or 8–10 dogs, respectively. Data be collected at patient level comprising (a) information about organization access tools, (b) history, path treatment during index consultation, (c) severity symptoms 7–10 days following inclusion, (d) urine culture (type microorganism susceptibility test). conducting future research, and/or designing common interventions, assessed by evaluating comparability respect implementation results. Results from give an insight into setting-up context. This crucial if are embrace approach, legitimate strategy interventions aimed influencing process order decrease inappropriate antibiotics. humans registered ClinicalTrials.gov NCT02249273 .