Sensitization against the parasite antigen Sj26 is not sufficient for consistent expression of resistance to Schistosoma japonicum in mice
作者： Graham F. Mitchell , Edito G. Garcia , Kathy M. Davern , Wilfred U. Tiu , Donald B. Smith
DOI: 10.1016/0035-9203(88)90027-2
关键词:
摘要: Mice immunized with purified antigen preparations produced in Escherichia coli and containing the glutathione S-transferase (GST) isoenzyme of Schistosoma japonicum (Sj26) can be partially resistant to infection this parasite. Maximum resistance was approximately 50% no protection obtained BALB/c mice, known low responders Sj26. Although only Freund's complete adjuvant has been used, data indicate that satisfactory levels S. will not attained by vaccination Sj26 alone. Other antigens, including additional GST Sj28, probably required establish whether an important component a defined multivalent vaccine against schistosomiasis japonica.
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