The effects of arginine starvation on macromolecular synthesis in infection with type 2 adenovirus

摘要: Abstract Although arginine deprivation inhibits the production of infectious type 2 adenovirus in KB cells, all major structural proteins can be detected acrylamide gel electropherograms infected cell material, including those peptides known to rich arginine. However, these viral synthesized during are largely unused assembly virions which occurs after is restored. With use a DNA inhibitor (FdUrd) and appropriate periods starvation, it shown that arginine-dependent function does not occur prior synthesis. The effects restoring at intervals late latent period indicate essential take place within 3–4 hr appearance mature virions, i.e., protein