Do we need to boost pertussis immunization within the existing UK vaccination schedule

摘要: Pertussis infection is associated with significant morbidity in younger children (<4 years), which can include pneumonia, seizures and encephalopathy. Around one 250 cases of pertussis infants under the age 6 months lead to death or severe brain damage. In United Kingdom control has been based on a three-dose schedule combined diphtheria, tetanus, whole-cell vaccine (DTPw) during first 4 life. Coverage rates for primary vaccination are currently at high levels over 90 per cent relatively low (approximately 1.2 100,000). However, there concerns potential under-reporting clear shifts pattern notified evident, surveillance data suggesting possible upward trend absolute numbers infections those most risk (i.e. <3 old). The addition childhood booster dose(s) standard clinical benefits may be cost-effective. Selective adult immunization also have role play controlling circulation pertussis.