Sirtuin 1 regulation of developmental genes during differentiation of stem cells
作者： Vincenzo Calvanese , Ester Lara , Beatriz Suárez-Álvarez , Raed Abu Dawud , Mercedes Vázquez-Chantada
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摘要: The longevity-promoting NAD+–dependent class III histone deacetylase Sirtuin 1 (SIRT1) is involved in stem cell function by controlling fate decision and/or regulating the p53-dependent expression of NANOG. We show that SIRT1 down-regulated precisely during human embryonic differentiation at both mRNA and protein levels decrease Sirt1 mediated a molecular pathway involves RNA-binding HuR arginine methyltransferase coactivator-associated (CARM1). down-regulation leads to reactivation key developmental genes such as neuroretinal morphogenesis effectors DLL4, TBX3, PAX6, which are epigenetically repressed this pluripotent cells. Our results indicate regulated context yet-unknown epigenetic controls specific
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