Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer

摘要: MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that function as negative gene regulators. miRNA deregulation is involved in the initiation and progression human cancer; however, underlying mechanism its contributions to genome-wide transcriptional changes cancer still largely unknown. We studied epithelial ovarian by integrative genomic approach, including microarray (n = 106), array-based comparative hybridization 109), cDNA 76), tissue array 504). expression markedly down-regulated malignant transformation tumor progression. Genomic copy number loss epigenetic silencing, respectively, may account for down-regulation ≈15% at least ≈36% miRNAs advanced tumors contributes a deregulation. Last, eight located chromosome 14 cluster (Dlk1-Gtl2 domain) were identified potential suppressor genes. Therefore, our results suggest offer new biomarkers therapeutic targets cancer.