Changes in arachidonic acid metabolism and the aggregation of polymorphonuclear leukocytes in rats with streptozotocin-induced diabetes
作者： Yasuhito Nakagawa , Erika Ishii
DOI: 10.1016/0925-4439(95)00116-6
关键词:
摘要: Changes in lipid composition were examined peritoneal polymorphonuclear leukocytes (PMNL) from rats with streptozotocin-induced diabetes. The largest changes associated the lipids PMNL prepared insulin-dependent diabetes mellitus found of fatty acids phospholipids although no consistent noted amounts individual classes. relative amount arachidonic acid was significantly reduced and that linoleic increased diabetic rats. extent A23187-stimulated release CGP IGP much smaller than normal PMNL. Moreover, there decreases production free its metabolites, such as LTB4 5-HETE by compared to Aggregation provoked A23187 suppressed However, addition or those resulted aggregation similar extents, a result supports role for enhanced availability endogenous induction present results suggest diabetes-associated metabolism might play critical modulation
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A.Q. Dang, F.H. Faas, J.A. Lee, W.J. Carter, Altered fatty acid composition in the plasma, platelets, and aorta of the streptozotocin-induced diabetic rat Metabolism-clinical and Experimental. ,vol. 37, pp. 1065- 1072 ,(1988) , 10.1016/0026-0495(88)90069-8
Cezary Watała, Zofia Jóźwiak, The phospholipid composition of erythrocyte ghosts and plasma lipoproteins in diabetes type 1 in children Clinica Chimica Acta. ,vol. 188, pp. 211- 219 ,(1990) , 10.1016/0009-8981(90)90202-4
Nakagawa Yasuhito, Waku Keizo, Ishima Yoshio, Changes in the composition of fatty chains of diacyl, alkylacyl and alkenylacyl ethanolamine and choline phosphoglycerides during the development of chick heart ventricular cells High accumulation of 22.carbon fatty acid in ether phospholipids Biochimica et Biophysica Acta. ,vol. 712, pp. 667- 676 ,(1982) , 10.1016/0005-2760(82)90296-X
P.H. Naccache, H.J. Showell, E.L. Becker, R.I. Sha'afi, Arachidonic acid induced degranulation of rabbit peritoneal neutrophils. Biochemical and Biophysical Research Communications. ,vol. 87, pp. 292- 299 ,(1979) , 10.1016/0006-291X(79)91678-4
M.L. Blank, Robert L. Wykle, Fred Snyder, The retention of arachidonic acid in ethanolamine plasmalogens of rat testes during essential fatty acid deficiency Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. ,vol. 316, pp. 28- 34 ,(1973) , 10.1016/0005-2760(73)90163-X
C. M. Nolan, H. N. Beaty, J. D. Bagdade, Further Characterization of the Impaired Bactericidal Function of Granulocytes in Patients with Poorly Controlled Diabetes Diabetes. ,vol. 27, pp. 889- 894 ,(1978) , 10.2337/DIAB.27.9.889
Stephen C. Cunnane, P. W. Napoleon Keeling, Richard P. H. Thompson, Michael A. Crawford, Linoleic acid and arachidonic acid metabolism in human peripheral blood leucocytes: comparison with the rat. British Journal of Nutrition. ,vol. 51, pp. 209- 217 ,(1984) , 10.1079/BJN19840025
Fred H. Faas, William J. Carter, Altered Microsomal Phospholipid Composition in the Streptozotocin Diabetic Rat Lipids. ,vol. 18, pp. 339- 342 ,(1983) , 10.1007/BF02534712
S GUDBJARNASON, A ELHAGE, V WHITEHURST, F SIMENTAL, T BALAZS, Reduced arachidonic acid levels in major phospholipids of heart muscle in the diabetic rat. Journal of Molecular and Cellular Cardiology. ,vol. 19, pp. 1141- 1146 ,(1987) , 10.1016/S0022-2828(87)80357-7
Robert J. Mason, Thomas P. Stossel, Martha Vaughan, Lipids of alveolar macrophages, polymorphonuclear leukocytes, and their phagocytic vesicles Journal of Clinical Investigation. ,vol. 51, pp. 2399- 2407 ,(1972) , 10.1172/JCI107052